Q&A: How does Avonex/Rebif/Betaseron treat Multiple Sclerosis?

Avonex_01IFN-b 1a (Avonex, Re-bif); IFNb 1b (Betaferon)

  • Functions: IFN-b reduces antigen presentation and thereby alters the proliferation of T cells. T cells, when activated and have the right capacity, can destroy myelin proteins that are essential for proper signal transduction. It also reduces the expression of metalloproteinase that is required for T cells to cross the blood brain barrier, thus reducing the number of T cells in the brain and indirectly alleviating the demyelination process.
  • Betaferon: first drug to treat relapsing-remitting MS. It reduces relapse rate by 30%.

For full list of immune-modulating treatments available for MS, click here