Homology of vIRFs with cellular IRFs

fimmu-02-00019-g003Cellular interferon regulatory factors (IRFs) are composed of a DNA-binding domain (DBD; green) and a regulatory domain (blue). The DBD of cellular IRFs is defined by 5 tryptophan (W) residues. Cellular IRFs may also contain an IRF-association domain (IAD) shown in yellow. Gray boxes indicate domains in the cellular IRF proteins that are homologous to each KSHV vIRF as determined by NCBI BLAST protein analysis (National Center for Biotechnological Information)



Front. Immunol., 17 June 2011 | doi: 10.3389/fimmu.2011.00019