Can our microbiome tells us much about ourselves?

Academic institutions, including University of Colorado and the University of Chicago, have already started focusing on microbiome research. It is very interesting to me when you come to realize that each human being is essentially a walking Petri dish. There is more bacteria in your body than the cells you have. Think about that – think about how much bacteria in your gut may possibly control your metabolism, your thoughts, or maybe even your life.

Microbiome startups, like ClostraBio, at the University of Chicago, spearheaded by immunologists and biomedical engineer, are looking into altering microbiome to cure food allergy. This is not it – microbiome may even have a bigger role than food allergy. I just came back from the second last day of ASCO – American Society of Clinical Oncology 2017. Microbiome diversity apparently is been linked to how well you will respond to immune therapy (PD-1 therapy, like Keytruda or Opdivo. Researchers found that responders to the therapy have different microbiome make-up than those who don’t respond. 

The story gets even more interesting. When they transplanted fecal matter (microbiome) from responders or non responders to germ free mice, they found that mice respond differently when they are xenografted with tumor cells.

They are now exploring the application of fecal transplantation and the use of probiotic in cancer treatment. 

Anyway, be aware of the power of these micro organisms in your gut!

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