Category Archives: Multiple Sclerosis QA

Q&A: How does mitoxantrone treat Multiple Sclerosis?

mitoxantrone-15210_2Mitoxantrone

  • Functions: It is a topoisomerase II inhibitor that interferes with DNA repair. It can also bind to DNA, so DNA and RNA replication is inhibition. It is found to suppress the proliferation of lymphocytes. And it can also inhibit the migration of macrophage into the central nervous system to suppress more inflammation.
  • Mitoxantrone: the only cytotoxic drug approved to treat relapsing remitting MS, progressive MS, progressive relapsing MS. Treatment for 2 years led to reduction of relapse rate by 64%.

For full list of immune-modulating treatments available for MS, click here

Q&A: How does laquinimod treat Multiple Sclerosis?

  • 607px-Laquinimod.svgLaquinimod
    • Functions: modulate cytokine secretion from peripheral blood lymphocytes; weaken pro-inflammation, impair cell traffick into the CNS
    • Laquinimod: can be administered orally. 0.6mg per day is shown to decrease the number of lesions by 40%. Currently Phase III trial is finished: company said the clinical trial has failed, but it is shown to reduce relapse rate and progression.

     

For full list of immune-modulating treatments available for MS, click here

Q&A: How does Copazone treat Multiple Sclerosis?

Copaxone2Glatiramer acetate (Copazone)

  • Functions: GA is a mixture of synthetic peptides to mimic a major component of the myelin protein. The mechanism of GA is unclear: it has been shown to differentiate naive T cells into Th2, increase regulatory T cells (that can inhibit proinflammatory T cells), modulate CD8 cytotoxic T cells, modulate B cells.
  • Copazone: demonstrated reduction of relapse rate of 30%

For full list of immune-modulating treatments available for MS, click here